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Associate Scientist Biochemical Assays and Antigenicity Screening | BSc, MSc | Leiden (NL)

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The company

Our client is a professional Pharmaceutical and Biotechnology organisation, based in Zuid-Holland Netherlands. Janssen Vaccines is committed to developing first-in-class or best-in-class vaccines for some of the world’s most life-threatening infectious diseases. We have built a dedicated, world-class, multi-functional team across a variety of disciplines to develop a promising vaccines pipeline. In Leiden, we have a workforce of 700 scientists and support staff, 45% of our employees has a nationality other than Dutch with over 20 nationalities represented. We partner with many of the world’s leading experts, academic and clinical institutions and other pharmaceutical companies for the development of vaccines against, for example, Ebola and HIV.

In our organization entrepreneurial people are working in a dynamic culture in which innovation and a 'can do' state of mind are the central points. In order to strengthen our team we are continuously looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to Janssen Vaccines.

Role description

The Bacterial Vaccine department is seeking a talented Associate Scientist (M.Sc. or B.Sc. with equivalent experience) to join the Biochemical assays and Antigenicity Screening group. The successful candidate will be part of a dynamic and highly motivated team driving the characterization/ and evaluation of large molecule entities that are being developed in different vaccine programmes. During your work, you will interact with various Bacterial Vaccines teams, and with Janssen Vaccine support departments. You will be expected to perform laboratory work in person and help contract research organizations (CROs) plan and execute their assignments.

The Bacterial Vaccines department is strengthening its biochemical assay capabilities, which are centered mainly on carbohydrate, protein and glycoprotein antigens. This position has therefore a strong focus on biochemical and immunological expertise. Apart from Bacterial Vaccines own resources, access to complementary analytical facilities is also possible within Janssen.

Responsibilities

• Chemical modification of bacterial surface molecules
• Analysis of antigen-antibody interactions
• Analyze carbohydrate, protein-, or glycoconjugate-based antigens.
• Know, implement and improve established tests for carbohydrates, proteins, glycoconjugates, and particle-based vaccines.
• Develop new biochemical methods (evaluate LoD, LoQ, accuracy, etc.)
• With help from product development specialists, design and implement biochemical assays for in-process control (IPC), product characterization, and product release.
• Support CROs to plan, execute, document, and review their work.

Requirements

• M.Sc. or B.Sc. with equivalent experience
• Minimal 2-4 years of professional experience (experience in an industry setting is a must).
• Experience with Biochemical analysis of carbohydrates, proteins and glycoconjugates.
• Significant knowledge on purification and enrichment of large biochemical entities
• Hands on experience on HPLC, colorimetric assays, ELISA, Cell based assays, labelling of biomolecules.

Other information

Are you interested and do want to apply for this role, please fill out your application via the apply button below and contact Cees Roffelsen.


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SIRE Life Sciences®

Placé par: SIRE Life Sciences®
Posté le: 15-04-2019
Pays: The Netherlands
Région: Zuid-Holland
Emploi: Permanent
Compétence: 3 - 5 années
Type de lieu: Sure place
Éducation: Bachelor
Langue: Anglais
Secteur: Pharmaceutique
Spécialisation: Recherche et développement

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